diff --git a/src/engine.ts b/src/engine.ts
index 3a93457..f2ad519 100644
--- a/src/engine.ts
+++ b/src/engine.ts
@@ -184,6 +184,13 @@ export function initializePolyfill() {
         instance?.disconnect();
       }
 
+      if (
+        entry.target.nodeType !== Node.DOCUMENT_NODE &&
+        entry.target.nodeType !== Node.DOCUMENT_FRAGMENT_NODE &&
+        entry.target.parentNode === null
+      ) {
+        continue;
+      }
       if (
         entry.type === 'attributes' &&
         entry.attributeName &&