diff --git a/.github/workflows/check.yml b/.github/workflows/check.yml
new file mode 100644
index 00000000..1bb27061
--- /dev/null
+++ b/.github/workflows/check.yml
@@ -0,0 +1,34 @@
+name: Checks
+
+on:
+  pull_request:
+    branches:
+    - master
+  push:
+    branches:
+    - master
+
+env:
+  PIP_DISABLE_PIP_VERSION_CHECK: '1'
+  PY_COLORS: '1'
+
+jobs:
+  check:
+    runs-on: ubuntu-latest
+    strategy:
+      fail-fast: false
+      matrix:
+        env:
+        #- ruff
+        #- black
+        - package
+    steps:
+    - uses: actions/checkout@v3
+    - uses: actions/setup-python@v4
+      with:
+        python-version: '3.10'
+    - name: Install build tools
+      run: |
+        python -m pip install tox wheel
+    - name: Run ${{ matrix.env }}
+      run: tox -e ${{ matrix.env }}
diff --git a/.github/workflows/publish.yml b/.github/workflows/publish.yml
new file mode 100644
index 00000000..9dd37a93
--- /dev/null
+++ b/.github/workflows/publish.yml
@@ -0,0 +1,29 @@
+name: Publish
+
+on:
+  push:
+    tags:
+    - '*'
+
+env:
+  PIP_DISABLE_PIP_VERSION_CHECK: '1'
+  PY_COLORS: '1'
+
+jobs:
+  publish:
+    runs-on: ubuntu-latest
+    steps:
+    - uses: actions/checkout@v3
+    - uses: actions/setup-python@v4
+      with:
+        python-version: '3.10'
+    - name: Install build tools
+      run: |
+        python -m pip install build twine wheel
+    - name: Build package
+      run: python -m build
+    - name: Upload to PyPI
+      env:
+        TWINE_USERNAME: ${{ secrets.PYPI_USERNAME }}
+        TWINE_PASSWORD: ${{ secrets.PYPI_PASSWORD }}
+      run: twine upload dist/*
diff --git a/.github/workflows/test.yml b/.github/workflows/test.yml
new file mode 100644
index 00000000..da420163
--- /dev/null
+++ b/.github/workflows/test.yml
@@ -0,0 +1,56 @@
+name: Tests
+
+on:
+  pull_request:
+    branches:
+    - master
+  push:
+    branches:
+    - master
+
+env:
+  PIP_DISABLE_PIP_VERSION_CHECK: '1'
+  PY_COLORS: '1'
+
+jobs:
+  test:
+    runs-on: ${{ matrix.platform }}
+    strategy:
+      fail-fast: false
+      matrix:
+        platform:
+        - ubuntu-20.04
+        - macos-latest
+        - windows-latest
+        python-version:
+        - '2.7'
+        - '3.5'
+        - '3.6'
+        - '3.7'
+        - '3.8'
+        - '3.9'
+        - '3.10'
+        - '3.11'
+        - pypy-2.7
+        - pypy-3.8
+        - pypy-3.9
+        dependencies:
+        - none
+        - scipy
+    steps:
+    - uses: actions/checkout@v3
+    - uses: actions/setup-python@v4
+      with:
+        python-version: ${{ matrix.python-version }}
+    - name: Install build tools
+      run: python -m pip install tox-gh-actions wheel
+    - name: Install optional dependencies
+      run: python -m pip install ${{ matrix.dependencies }}
+      if: ${{ matrix.dependencies != 'none' }}
+    - name: Run tests
+      run: tox
+    - name: Upload coverage report
+      uses: codacy/codacy-coverage-reporter-action@v1
+      with:
+        project-token: ${{ secrets.CODACY_PROJECT_TOKEN }}
+        coverage-reports: coverage.xml
diff --git a/.gitignore b/.gitignore
index 3d04dc2a..cb7301dc 100644
--- a/.gitignore
+++ b/.gitignore
@@ -1,15 +1,69 @@
-*.pyc
-scratch/
-examples/data
-.idea/
-.DS_Store
+__pycache__/
+*.py[cod]
+*$py.class
+
+# Distribution / packaging
+.Python
 build/
-data/
+develop-eggs/
 dist/
+downloads/
+eggs/
+.eggs/
+lib/
+lib64/
+parts/
+sdist/
+var/
+wheels/
+*.egg-info/
+.installed.cfg
+*.egg
 MANIFEST
+
+# Installer logs
+pip-log.txt
+pip-delete-this-directory.txt
+
+# Unit test / coverage reports
+htmlcov/
+.tox/
+.coverage
+.coverage.*
+.cache
+coverage.*
+*.cover
+.hypothesis/
+nosetests.xml
+.pytest_cache/
+junit-report.xml
+
+# pyenv
+.python-version
+
+# Environments
+.env
+.venv
+env/
+venv/
+ENV/
+env.bak/
+venv.bak/
+
+# mypy
+.mypy_cache/
+
+# OS and IDE config files
+.DS_Store
+.idea/
+
+# project-specific
+data/
 *.so
 *.c
+scratch/
+examples/data
+
 .asv/
-autograd.egg-info/
 asv.conf.json
 benchmarks/asv.conf.js
diff --git a/.travis.yml b/.travis.yml
deleted file mode 100644
index a360e8fa..00000000
--- a/.travis.yml
+++ /dev/null
@@ -1,26 +0,0 @@
-sudo: false
-notifications:
-  email: false
-language: python
-python:
-  - "2.7"
-  - "3.6"
-env:
-  - DEPS="pip pytest future numpy scipy"
-  - DEPS="pip pytest future numpy"
-before_install:
-  - if [[ "$TRAVIS_PYTHON_VERSION" == "2.7" ]]; then
-      wget https://repo.continuum.io/miniconda/Miniconda2-latest-Linux-x86_64.sh -O miniconda.sh;
-    else
-      wget https://repo.continuum.io/miniconda/Miniconda3-latest-Linux-x86_64.sh -O miniconda.sh;
-    fi
-  - bash miniconda.sh -b -p $HOME/miniconda
-  - export PATH="$HOME/miniconda/bin:$PATH"
-  - conda update --yes conda
-  - conda config --add channels conda-forge
-install:
-  - conda install --yes python=$TRAVIS_PYTHON_VERSION $DEPS
-  - pip install -v .
-script: 
-  - (cd tests; python -mpytest .)  # Run from inside tests directory to make sure
-  -                                # Autograd has fully installed.
diff --git a/CONTRIBUTING.md b/CONTRIBUTING.md
new file mode 100644
index 00000000..d20ca31e
--- /dev/null
+++ b/CONTRIBUTING.md
@@ -0,0 +1,43 @@
+# Contributing
+
+Use Tox to run tests and linting, e.g.
+
+```shell
+pip install tox
+```
+
+## Run tests, linting, packaging checks
+
+```shell
+tox list                # list all Tox environments
+tox run -e black,ruff   # run code style checks
+tox run -e py           # run tests with your default Python
+tox run -e package      # verify packaging
+tox                     # run all Tox environments
+```
+
+Make sure all tests pass before you push your changes to GitHub.
+GH Actions will run the tests across all supported Python versions.
+
+## Using arguments (reformat, upload package, help)
+
+You can use additional arguments for the tools called by Tox by
+separating them from the Tox arguments by a double-dash `--`, e.g.
+
+```shell
+tox run -e black -- autograd/core.py --check --diff
+tox run -e black -- autograd/core.py
+```
+
+```shell
+tox run -e ruff -- autograd/core.py --show-source
+tox run -e ruff -- autograd/core.py --fix
+```
+
+```shell
+tox run -e package -- upload
+```
+
+```shell
+tox run -e py -- --help
+```
diff --git a/MANIFEST.in b/MANIFEST.in
index f0fd68f8..a3e17ed3 100644
--- a/MANIFEST.in
+++ b/MANIFEST.in
@@ -1 +1,2 @@
 recursive-include autograd *.c *.h *.pyx
+prune tests
diff --git a/README.md b/README.md
index 140896ad..9bfeb520 100644
--- a/README.md
+++ b/README.md
@@ -4,7 +4,15 @@ Townsend) are now working on [JAX](https://github.com/google/jax), with Dougal a
 working on it full-time. JAX combines a new version of Autograd with extra
 features such as jit compilation.__
 
-# Autograd  [![Test status](https://travis-ci.org/HIPS/autograd.svg?branch=master)](https://travis-ci.org/HIPS/autograd) [![asv](http://img.shields.io/badge/benchmarked%20by-asv-green.svg?style=flat)](#)
+# Autograd  [![Checks status][checks-badge]][checks-url] [![Tests status][tests-badge]][tests-url] [![Publish status][publish-badge]][publish-url] [![asv][asv-badge]](#)
+
+[publish-badge]: https://github.com/HIPS/autograd/actions/workflows/publish.yml/badge.svg
+[checks-badge]: https://github.com/HIPS/autograd/actions/workflows/check.yml/badge.svg
+[tests-badge]: https://github.com/HIPS/autograd/actions/workflows/test.yml/badge.svg
+[asv-badge]: http://img.shields.io/badge/benchmarked%20by-asv-green.svg?style=flat
+[publish-url]: https://github.com/HIPS/autograd/actions/workflows/publish.yml
+[checks-url]: https://github.com/HIPS/autograd/actions/workflows/check.yml
+[tests-url]: https://github.com/HIPS/autograd/actions/workflows/test.yml
 
 Autograd can automatically differentiate native Python and Numpy code. It can
 handle a large subset of Python's features, including loops, ifs, recursion and
@@ -75,7 +83,18 @@ You can find a tutorial [here.](docs/tutorial.md)
 
 ## How to install
 
-Just run `pip install autograd`
+Install _autograd_ using Pip, e.g.
+
+```shell
+pip install autograd
+```
+
+Some features require _scipy_, which you can install separately or as an
+optional dependency along with _autograd_ , e.g.
+
+```shell
+pip install "autograd[scipy]"
+```
 
 ## Authors
 
diff --git a/autograd/builtins.py b/autograd/builtins.py
index 8db7c238..39880fd5 100644
--- a/autograd/builtins.py
+++ b/autograd/builtins.py
@@ -1,5 +1,4 @@
-import itertools
-from future.utils import with_metaclass
+from six import with_metaclass
 from .util import subvals
 from .extend import (Box, primitive, notrace_primitive, VSpace, vspace,
                      SparseObject, defvjp, defvjp_argnum, defjvp, defjvp_argnum)
diff --git a/autograd/numpy/numpy_vjps.py b/autograd/numpy/numpy_vjps.py
index aab566f8..774afa92 100644
--- a/autograd/numpy/numpy_vjps.py
+++ b/autograd/numpy/numpy_vjps.py
@@ -1,5 +1,5 @@
 from __future__ import absolute_import
-from future.utils import string_types
+from six import string_types
 from functools import partial
 import numpy as onp
 from ..util import func
diff --git a/autograd/scipy/signal.py b/autograd/scipy/signal.py
index 44bed02c..e1f0d650 100644
--- a/autograd/scipy/signal.py
+++ b/autograd/scipy/signal.py
@@ -6,7 +6,7 @@
 from autograd.extend import primitive, defvjp
 
 from numpy.lib.stride_tricks import as_strided
-from future.utils import iteritems
+from six import iteritems
 
 @primitive
 def convolve(A, B, axes=None, dot_axes=[(),()], mode='full'):
diff --git a/examples/data_mnist.py b/examples/data_mnist.py
index 6dcff1d2..21df35d8 100644
--- a/examples/data_mnist.py
+++ b/examples/data_mnist.py
@@ -1,7 +1,9 @@
 from __future__ import absolute_import
 from __future__ import print_function
-from future.standard_library import install_aliases
-install_aliases()
+import sys
+if sys.version < "3":
+    from future.standard_library import install_aliases
+    install_aliases()
 
 import os
 import gzip
diff --git a/pyproject.toml b/pyproject.toml
new file mode 100644
index 00000000..02f71ec9
--- /dev/null
+++ b/pyproject.toml
@@ -0,0 +1,73 @@
+[build-system]
+requires = ["setuptools>=63"]
+build-backend = "setuptools.build_meta"
+
+[project]
+name = "autograd"
+version = "1.6.3"
+description = "Efficiently computes derivatives of numpy code."
+readme = "README.md"
+license = {file = "license.txt"}
+authors = [
+  {name = "Dougal Maclaurin", email = "maclaurin@physics.harvard.edu"},
+  {name = "David Duvenaud", email = "duvenaud@cs.toronto.edu"},
+  {name = "Matthew Johnson", email = "mattjj@csail.mit.edu"},
+]
+maintainers = [
+  {name = "Jamie Townsend", email = "jamiehntownsend@gmail.com"},
+]
+classifiers = [
+  "Development Status :: 4 - Beta",
+  "Intended Audience :: Information Technology",
+  "Intended Audience :: Science/Research",
+  "License :: OSI Approved :: MIT License",
+  "Programming Language :: Python :: 2",
+  "Programming Language :: Python :: 2.7",
+  "Programming Language :: Python :: 3",
+  "Programming Language :: Python :: 3.5",
+  "Programming Language :: Python :: 3.6",
+  "Programming Language :: Python :: 3.7",
+  "Programming Language :: Python :: 3.8",
+  "Programming Language :: Python :: 3.9",
+  "Programming Language :: Python :: 3.10",
+  "Programming Language :: Python :: 3.11",
+]
+keywords = [
+  "Automatic differentiation",
+  "backpropagation",
+  "gradients",
+  "machine learning",
+  "optimization",
+  "neural networks",
+  "Python",
+  "Numpy",
+  "Scipy",
+]
+dependencies = [
+  "numpy>=1.12",
+  "six",
+  "future>=0.15.2; python_version < '3'",
+]
+
+[project.optional-dependencies]
+scipy = [
+  "scipy",
+]
+
+[tool.coverage.run]
+source = ["autograd"]
+
+[tool.coverage.report]
+show_missing = true
+
+[tool.pytest.ini_options]
+addopts = "--color=yes --junitxml=junit-report.xml"
+
+[tool.setuptools]
+packages=[
+  "autograd",
+  "autograd.numpy",
+  "autograd.scipy",
+  "autograd.scipy.stats",
+  "autograd.misc",
+]
diff --git a/setup.cfg b/setup.cfg
deleted file mode 100644
index b88034e4..00000000
--- a/setup.cfg
+++ /dev/null
@@ -1,2 +0,0 @@
-[metadata]
-description-file = README.md
diff --git a/setup.py b/setup.py
deleted file mode 100644
index d352318e..00000000
--- a/setup.py
+++ /dev/null
@@ -1,20 +0,0 @@
-from setuptools import setup
-
-setup(
-    name='autograd',
-    version='1.6.2',
-    description='Efficiently computes derivatives of numpy code.',
-    author='Dougal Maclaurin and David Duvenaud and Matthew Johnson',
-    author_email="maclaurin@physics.harvard.edu, duvenaud@cs.toronto.edu, mattjj@csail.mit.edu",
-    packages=['autograd', 'autograd.numpy', 'autograd.scipy', 'autograd.scipy.stats', 'autograd.misc'],
-    install_requires=['numpy>=1.12', 'future>=0.15.2'],
-    keywords=['Automatic differentiation', 'backpropagation', 'gradients',
-              'machine learning', 'optimization', 'neural networks',
-              'Python', 'Numpy', 'Scipy'],
-    url='https://github.com/HIPS/autograd',
-    license='MIT',
-    classifiers=['Development Status :: 4 - Beta',
-                 'License :: OSI Approved :: MIT License',
-                 'Programming Language :: Python :: 2.7',
-                 'Programming Language :: Python :: 3.5'],
-)
diff --git a/tox.ini b/tox.ini
new file mode 100644
index 00000000..8ad433f8
--- /dev/null
+++ b/tox.ini
@@ -0,0 +1,76 @@
+# Tox (https://tox.wiki/) - run tests in isolation using virtualenv.
+# Also contains config settings for tools that don't look into pyproject.toml.
+
+[tox]
+envlist =
+    ruff
+    black
+    py2{7}
+    pypy2{7}
+    py3{5,6,7,8,9,10,11}
+    pypy3{8,9}
+    package
+    clean
+
+[gh-actions]
+python =
+    2.7: py27
+    3.5: py35
+    3.6: py36
+    3.7: py37
+    3.8: py38
+    3.9: py39
+    3.10: py310
+    3.11: py311
+    pypy-2.7: pypy27
+    pypy-3.8: pypy38
+    pypy-3.9: pypy39
+
+[testenv]
+description = Unit tests and test coverage
+deps =
+    py27: mock
+    pypy27: mock
+    coverage[toml]
+    pytest
+commands =
+    coverage run -m pytest {posargs}
+    coverage xml
+    coverage report
+
+[testenv:black]
+description = Ensure consistent code style
+skip_install = true
+deps = black
+commands = black {posargs:. --check}
+
+[testenv:clean]
+description = Clean up bytecode and build artifacts
+skip_install = true
+deps = pyclean
+commands = pyclean {posargs:. --debris --erase junit-report.xml --yes}
+
+[testenv:ruff]
+description = Lightening-fast linting for Python
+skip_install = true
+deps = ruff
+commands = ruff {posargs:.}
+
+[testenv:package]
+description = Build package and check metadata (or upload package)
+skip_install = true
+deps =
+    build
+    twine
+commands =
+    python -m build
+    twine {posargs:check --strict} dist/*
+passenv =
+    TWINE_USERNAME
+    TWINE_PASSWORD
+    TWINE_REPOSITORY_URL
+
+[pytest]
+addopts =
+    --color=yes
+    --junitxml=junit-report.xml