diff --git a/.github/workflows/test.yml b/.github/workflows/test.yml
index d48e716b..20c5db96 100644
--- a/.github/workflows/test.yml
+++ b/.github/workflows/test.yml
@@ -31,25 +31,21 @@ jobs:
         - pypy-3.7
         - pypy-3.8
         - pypy-3.9
-        extras:
-        - none
-        - scipy
+        - pypy-3.10
+        exclude:
+        - { platform: windows-latest, python-version: pypy-3.7 }
     steps:
     - uses: actions/checkout@v3
     - uses: actions/setup-python@v4
       with:
         python-version: ${{ matrix.python-version }}
     - name: Install Python build tools
-      if: matrix.python-version != 'pypy-3.7' || matrix.platform != 'windows-latest'
-      run: python -m pip install tox-gh-actions wheel
-    - name: Workaround for PyPy 3.7 on Windows (tox-conda)
-      if: matrix.python-version == 'pypy-3.7' && matrix.platform == 'windows-latest'
-      run: python -m pip install tox-conda tox-gh-actions wheel
-    - name: Install optional dependencies (extras) on Linux/macOS
-      if: matrix.extras != 'none' && matrix.platform != 'windows-latest'
-      run: conda install -c anaconda ${{ matrix.extras }}
-    - name: Install optional dependencies (extras) on Windows
-      if: matrix.extras != 'none' && matrix.platform == 'windows-latest'
-      run: . ${env:CONDA}\scripts\conda.exe install -c anaconda ${{ matrix.extras }}
+      run: python -m pip install tox wheel
     - name: Run tests
-      run: tox
+      run: tox run -e py
+    - name: Install Scipy prerequisites for Ubuntu
+      if: startsWith(matrix.platform, 'ubuntu')
+      run: sudo apt-get install libopenblas-dev
+    - name: Run tests with scipy
+      if: startsWith(matrix.platform, 'ubuntu') || startsWith(matrix.python-version, 'pypy') != true
+      run: tox run -e py-scipy
diff --git a/pyproject.toml b/pyproject.toml
index fe57aaf1..9bf24861 100644
--- a/pyproject.toml
+++ b/pyproject.toml
@@ -1,5 +1,5 @@
 [build-system]
-requires = ["setuptools>=63"]
+requires = ["setuptools>=44"]
 build-backend = "setuptools.build_meta"
 
 [project]
diff --git a/tox.ini b/tox.ini
index e3828855..848921c2 100644
--- a/tox.ini
+++ b/tox.ini
@@ -4,26 +4,13 @@
 [tox]
 envlist =
     ruff
-    py2{7}
-    pypy2{7}
-    py3{5,6,7,8,9,10,11}
-    pypy3{8,9}
+    py2{7}{,-scipy}
+    pypy2{7}{,-scipy}
+    py3{5,6,7,8,9,10,11}{,-scipy}
+    pypy3{8,9,10}{,-scipy}
     package
     clean
-
-[gh-actions]
-python =
-    2.7: py27
-    3.5: py35
-    3.6: py36
-    3.7: py37
-    3.8: py38
-    3.9: py39
-    3.10: py310
-    3.11: py311
-    pypy-2.7: pypy27
-    pypy-3.8: pypy38
-    pypy-3.9: pypy39
+requires = virtualenv<20.22.0
 
 [testenv]
 description = Unit tests and test coverage
@@ -32,6 +19,8 @@ deps =
     pypy27: mock
     coverage[toml]
     pytest
+extras =
+    scipy: scipy
 commands =
     coverage run -m pytest {posargs}
     coverage xml