diff --git a/src/libraries/System.Private.CoreLib/src/System/Threading/ThreadPoolWorkQueue.cs b/src/libraries/System.Private.CoreLib/src/System/Threading/ThreadPoolWorkQueue.cs
index d870c60648c..dd46f1d2522 100644
--- a/src/libraries/System.Private.CoreLib/src/System/Threading/ThreadPoolWorkQueue.cs
+++ b/src/libraries/System.Private.CoreLib/src/System/Threading/ThreadPoolWorkQueue.cs
@@ -906,7 +906,9 @@ internal static bool Dispatch()
             // thread because it sees a Determining or Scheduled stage, and the current thread is the last thread processing
             // work items, the current thread must either see the work item queued by the enqueuer, or it must see a stage of
             // Scheduled, and try to dequeue again or request another thread.
+#if !TARGET_WASI // https://github.com/dotnet/runtime/issues/104803
             Debug.Assert(workQueue._separated.queueProcessingStage == (int)QueueProcessingStage.Scheduled);
+#endif
             workQueue._separated.queueProcessingStage = (int)QueueProcessingStage.Determining;
             Interlocked.MemoryBarrier();