diff --git a/packages/react-native/ReactCommon/jsc/JSCRuntime.cpp b/packages/react-native/ReactCommon/jsc/JSCRuntime.cpp
index fea1d0bc2d33c7..90a11df160a106 100644
--- a/packages/react-native/ReactCommon/jsc/JSCRuntime.cpp
+++ b/packages/react-native/ReactCommon/jsc/JSCRuntime.cpp
@@ -398,6 +398,13 @@ JSCRuntime::JSCRuntime(JSGlobalContextRef ctx)
       stringCounter_(0)
 #endif
 {
+#ifndef NDEBUG
+#ifdef TARGET_OS_MAC
+  if (__builtin_available(macOS 13.3, iOS 16.4, tvOS 16.4, *)) {
+    JSGlobalContextSetInspectable(ctx_, true);
+  }
+#endif
+#endif
 }
 
 JSCRuntime::~JSCRuntime() {