diff --git a/src/response.ts b/src/response.ts
index ac67c00..1f4fb59 100644
--- a/src/response.ts
+++ b/src/response.ts
@@ -4,30 +4,33 @@ import type { OutgoingHttpHeaders } from 'node:http'
 import { buildOutgoingHttpHeaders } from './utils'
 
 const responseCache = Symbol('responseCache')
-const newGlobalResponseKey = Symbol('newGlobalResponse')
 export const cacheKey = Symbol('cache')
 
 export const GlobalResponse = global.Response
 export class Response {
   #body?: BodyInit | null
-  #init?: ResponseInit;
+  #init?: ResponseInit
 
-  [newGlobalResponseKey](): typeof GlobalResponse {
-    return new GlobalResponse(
-      this.#body,
-      this.#init instanceof Response ? this.#init[newGlobalResponseKey]() : (this.#init as any)
-    ) as any
-  }
-
-  // @ts-ignore
   private get cache(): typeof GlobalResponse {
     delete (this as any)[cacheKey]
-    return ((this as any)[responseCache] ||= this[newGlobalResponseKey]())
+    return ((this as any)[responseCache] ||= new GlobalResponse(this.#body, this.#init))
   }
 
   constructor(body?: BodyInit | null, init?: ResponseInit) {
     this.#body = body
-    this.#init = init
+    if (init instanceof Response) {
+      const cachedGlobalResponse = (init as any)[responseCache]
+      if (cachedGlobalResponse) {
+        this.#init = cachedGlobalResponse
+        // instantiate GlobalResponse cache and this object always returns value from global.Response
+        this.cache
+        return
+      } else {
+        this.#init = init.#init
+      }
+    } else {
+      this.#init = init
+    }
 
     if (typeof body === 'string' || body instanceof ReadableStream) {
       let headers = (init?.headers || { 'content-type': 'text/plain;charset=UTF-8' }) as
@@ -38,7 +41,7 @@ export class Response {
         headers = buildOutgoingHttpHeaders(headers)
       }
 
-      (this as any)[cacheKey] = [init?.status || 200, body, headers]
+      ;(this as any)[cacheKey] = [init?.status || 200, body, headers]
     }
   }
 }
diff --git a/test/response.test.ts b/test/response.test.ts
index 6be4071..7b7be84 100644
--- a/test/response.test.ts
+++ b/test/response.test.ts
@@ -4,6 +4,18 @@ import { GlobalResponse } from '../src/response'
 
 class NextResponse extends Response {}
 
+class UpperCaseStream extends TransformStream {
+  constructor() {
+    super({
+      transform(chunk, controller) {
+        controller.enqueue(
+          new TextEncoder().encode(new TextDecoder().decode(chunk).toString().toUpperCase())
+        )
+      },
+    })
+  }
+}
+
 describe('Response', () => {
   let server: Server
   let port: number
@@ -54,14 +66,27 @@ describe('Response', () => {
 
     // support other class to extends from Response
     expect(new NextResponse()).toBeInstanceOf(Response)
+  })
 
+  it('Should not lose header data', async () => {
     const parentResponse = new Response('OK', {
       headers: {
         'content-type': 'application/json',
-      }
+      },
     })
     const childResponse = new Response('OK', parentResponse)
     parentResponse.headers.delete('content-type')
     expect(childResponse.headers.get('content-type')).toEqual('application/json')
   })
+
+  it('Nested constructors should not cause an error even if ReadableStream is specified', async () => {
+    const stream = new Response('hono').body
+    const parentResponse = new Response(stream)
+    const upperCaseStream = new UpperCaseStream()
+    const childResponse = new Response(
+      parentResponse.body!.pipeThrough(upperCaseStream),
+      parentResponse
+    )
+    expect(await childResponse.text()).toEqual('HONO')
+  })
 })