diff --git a/changelog.d/15272.misc b/changelog.d/15272.misc
new file mode 100644
index 000000000000..7a3ef323e9aa
--- /dev/null
+++ b/changelog.d/15272.misc
@@ -0,0 +1 @@
+Remove unused class `DirectTcpReplicationClientFactory`.
diff --git a/synapse/replication/tcp/client.py b/synapse/replication/tcp/client.py
index 424854efbe52..200f667fdf27 100644
--- a/synapse/replication/tcp/client.py
+++ b/synapse/replication/tcp/client.py
@@ -18,16 +18,12 @@
 
 from twisted.internet import defer
 from twisted.internet.defer import Deferred
-from twisted.internet.interfaces import IAddress, IConnector
-from twisted.internet.protocol import ReconnectingClientFactory
-from twisted.python.failure import Failure
 
 from synapse.api.constants import EventTypes, Membership, ReceiptTypes
 from synapse.federation import send_queue
 from synapse.federation.sender import FederationSender
 from synapse.logging.context import PreserveLoggingContext, make_deferred_yieldable
 from synapse.metrics.background_process_metrics import run_as_background_process
-from synapse.replication.tcp.protocol import ClientReplicationStreamProtocol
 from synapse.replication.tcp.streams import (
     AccountDataStream,
     DeviceListsStream,
@@ -53,7 +49,6 @@
 from synapse.util.metrics import Measure
 
 if TYPE_CHECKING:
-    from synapse.replication.tcp.handler import ReplicationCommandHandler
     from synapse.server import HomeServer
 
 logger = logging.getLogger(__name__)
@@ -62,52 +57,6 @@
 _WAIT_FOR_REPLICATION_TIMEOUT_SECONDS = 5
 
 
-class DirectTcpReplicationClientFactory(ReconnectingClientFactory):
-    """Factory for building connections to the master. Will reconnect if the
-    connection is lost.
-
-    Accepts a handler that is passed to `ClientReplicationStreamProtocol`.
-    """
-
-    initialDelay = 0.1
-    maxDelay = 1  # Try at least once every N seconds
-
-    def __init__(
-        self,
-        hs: "HomeServer",
-        client_name: str,
-        command_handler: "ReplicationCommandHandler",
-    ):
-        self.client_name = client_name
-        self.command_handler = command_handler
-        self.server_name = hs.config.server.server_name
-        self.hs = hs
-        self._clock = hs.get_clock()  # As self.clock is defined in super class
-
-        hs.get_reactor().addSystemEventTrigger("before", "shutdown", self.stopTrying)
-
-    def startedConnecting(self, connector: IConnector) -> None:
-        logger.info("Connecting to replication: %r", connector.getDestination())
-
-    def buildProtocol(self, addr: IAddress) -> ClientReplicationStreamProtocol:
-        logger.info("Connected to replication: %r", addr)
-        return ClientReplicationStreamProtocol(
-            self.hs,
-            self.client_name,
-            self.server_name,
-            self._clock,
-            self.command_handler,
-        )
-
-    def clientConnectionLost(self, connector: IConnector, reason: Failure) -> None:
-        logger.error("Lost replication conn: %r", reason)
-        ReconnectingClientFactory.clientConnectionLost(self, connector, reason)
-
-    def clientConnectionFailed(self, connector: IConnector, reason: Failure) -> None:
-        logger.error("Failed to connect to replication: %r", reason)
-        ReconnectingClientFactory.clientConnectionFailed(self, connector, reason)
-
-
 class ReplicationDataHandler:
     """Handles incoming stream updates from replication.