diff --git a/docs/pages/api-docs/card-content.json b/docs/pages/api-docs/card-content.json
index c0b94494591be0..a9d46900c13957 100644
--- a/docs/pages/api-docs/card-content.json
+++ b/docs/pages/api-docs/card-content.json
@@ -2,7 +2,8 @@
   "props": {
     "children": { "type": { "name": "node" } },
     "classes": { "type": { "name": "object" } },
-    "component": { "type": { "name": "elementType" } }
+    "component": { "type": { "name": "elementType" } },
+    "sx": { "type": { "name": "object" } }
   },
   "name": "CardContent",
   "styles": { "classes": ["root"], "globalClasses": {}, "name": "MuiCardContent" },
@@ -11,6 +12,6 @@
   "filename": "/packages/material-ui/src/CardContent/CardContent.js",
   "inheritance": null,
   "demos": "<ul><li><a href=\"/components/cards/\">Cards</a></li></ul>",
-  "styledComponent": false,
+  "styledComponent": true,
   "cssComponent": false
 }
diff --git a/docs/translations/api-docs/card-content/card-content.json b/docs/translations/api-docs/card-content/card-content.json
index 9fbaf3f4099185..040b25c849be29 100644
--- a/docs/translations/api-docs/card-content/card-content.json
+++ b/docs/translations/api-docs/card-content/card-content.json
@@ -3,7 +3,8 @@
   "propDescriptions": {
     "children": "The content of the component.",
     "classes": "Override or extend the styles applied to the component. See <a href=\"#css\">CSS API</a> below for more details.",
-    "component": "The component used for the root node. Either a string to use a HTML element or a component."
+    "component": "The component used for the root node. Either a string to use a HTML element or a component.",
+    "sx": "The system prop that allows defining system overrides as well as additional CSS styles. See the <a href=\"/system/basics/#the-sx-prop\">`sx` page</a> for more details."
   },
   "classDescriptions": { "root": { "description": "Styles applied to the root element." } }
 }
diff --git a/packages/material-ui/src/CardContent/CardContent.d.ts b/packages/material-ui/src/CardContent/CardContent.d.ts
index ca35743820e0eb..476d22b4f782c6 100644
--- a/packages/material-ui/src/CardContent/CardContent.d.ts
+++ b/packages/material-ui/src/CardContent/CardContent.d.ts
@@ -1,5 +1,7 @@
 import * as React from 'react';
+import { SxProps } from '@material-ui/system';
 import { OverridableComponent, OverrideProps } from '../OverridableComponent';
+import { Theme } from '..';
 
 export interface CardContentTypeMap<P = {}, D extends React.ElementType = 'div'> {
   props: P & {
@@ -14,6 +16,10 @@ export interface CardContentTypeMap<P = {}, D extends React.ElementType = 'div'>
       /** Styles applied to the root element. */
       root?: string;
     };
+    /**
+     * The system prop that allows defining system overrides as well as additional CSS styles.
+     */
+    sx?: SxProps<Theme>;
   };
   defaultComponent: D;
 }
diff --git a/packages/material-ui/src/CardContent/CardContent.js b/packages/material-ui/src/CardContent/CardContent.js
index 93fbfdc0e71b33..513748de2f1916 100644
--- a/packages/material-ui/src/CardContent/CardContent.js
+++ b/packages/material-ui/src/CardContent/CardContent.js
@@ -1,22 +1,62 @@
 import * as React from 'react';
 import PropTypes from 'prop-types';
 import clsx from 'clsx';
-import withStyles from '../styles/withStyles';
+import { unstable_composeClasses as composeClasses } from '@material-ui/unstyled';
+import experimentalStyled from '../styles/experimentalStyled';
+import useThemeProps from '../styles/useThemeProps';
+import { getCardContentUtilityClass } from './cardContentClasses';
 
-export const styles = {
+const overridesResolver = (props, styles) => styles.root || {};
+
+const useUtilityClasses = (styleProps) => {
+  const { classes } = styleProps;
+
+  const slots = {
+    root: ['root'],
+  };
+
+  return composeClasses(slots, getCardContentUtilityClass, classes);
+};
+
+const CardContentRoot = experimentalStyled(
+  'div',
+  {},
+  {
+    name: 'MuiCardContent',
+    slot: 'Root',
+    overridesResolver,
+  },
+)(() => {
   /* Styles applied to the root element. */
-  root: {
+  return {
     padding: 16,
     '&:last-child': {
       paddingBottom: 24,
     },
-  },
-};
+  };
+});
+
+const CardContent = React.forwardRef(function CardContent(inProps, ref) {
+  const props = useThemeProps({
+    props: inProps,
+    name: 'MuiCardContent',
+  });
+
+  const { className, component = 'div', ...other } = props;
 
-const CardContent = React.forwardRef(function CardContent(props, ref) {
-  const { classes, className, component: Component = 'div', ...other } = props;
+  const styleProps = { ...props, component };
 
-  return <Component className={clsx(classes.root, className)} ref={ref} {...other} />;
+  const classes = useUtilityClasses(styleProps);
+
+  return (
+    <CardContentRoot
+      as={component}
+      className={clsx(classes.root, className)}
+      styleProps={styleProps}
+      ref={ref}
+      {...other}
+    />
+  );
 });
 
 CardContent.propTypes = {
@@ -41,6 +81,10 @@ CardContent.propTypes = {
    * Either a string to use a HTML element or a component.
    */
   component: PropTypes.elementType,
+  /**
+   * The system prop that allows defining system overrides as well as additional CSS styles.
+   */
+  sx: PropTypes.object,
 };
 
-export default withStyles(styles, { name: 'MuiCardContent' })(CardContent);
+export default CardContent;
diff --git a/packages/material-ui/src/CardContent/CardContent.test.js b/packages/material-ui/src/CardContent/CardContent.test.js
index 6eea231c090e00..3b7d7e48d540b2 100644
--- a/packages/material-ui/src/CardContent/CardContent.test.js
+++ b/packages/material-ui/src/CardContent/CardContent.test.js
@@ -1,20 +1,18 @@
 import * as React from 'react';
-import { getClasses, createMount, describeConformance } from 'test/utils';
+import { createMount, describeConformanceV5 } from 'test/utils';
 import CardContent from './CardContent';
+import classes from './cardContentClasses';
 
 describe('<CardContent />', () => {
   const mount = createMount();
-  let classes;
 
-  before(() => {
-    classes = getClasses(<CardContent />);
-  });
-
-  describeConformance(<CardContent />, () => ({
+  describeConformanceV5(<CardContent />, () => ({
     classes,
     inheritComponent: 'div',
     mount,
+    muiName: 'MuiCardContent',
     refInstanceof: window.HTMLDivElement,
+    skip: ['componentsProp', 'themeVariants'],
     testComponentPropWith: 'span',
   }));
 });
diff --git a/packages/material-ui/src/CardContent/cardContentClasses.d.ts b/packages/material-ui/src/CardContent/cardContentClasses.d.ts
new file mode 100644
index 00000000000000..41ee3c26c41405
--- /dev/null
+++ b/packages/material-ui/src/CardContent/cardContentClasses.d.ts
@@ -0,0 +1,9 @@
+export interface CardContentClasses {
+  root: string;
+}
+
+declare const cardContentClasses: CardContentClasses;
+
+export function getCardContentUtilityClass(slot: string): string;
+
+export default cardContentClasses;
diff --git a/packages/material-ui/src/CardContent/cardContentClasses.js b/packages/material-ui/src/CardContent/cardContentClasses.js
new file mode 100644
index 00000000000000..b156806da5a937
--- /dev/null
+++ b/packages/material-ui/src/CardContent/cardContentClasses.js
@@ -0,0 +1,9 @@
+import { generateUtilityClass, generateUtilityClasses } from '@material-ui/unstyled';
+
+export function getCardContentUtilityClass(slot) {
+  return generateUtilityClass('MuiCardContent', slot);
+}
+
+const cardContentClasses = generateUtilityClasses('MuiCardContent', ['root']);
+
+export default cardContentClasses;
diff --git a/packages/material-ui/src/CardContent/index.d.ts b/packages/material-ui/src/CardContent/index.d.ts
index a217109e6ac419..76f1a0d2ab8e67 100644
--- a/packages/material-ui/src/CardContent/index.d.ts
+++ b/packages/material-ui/src/CardContent/index.d.ts
@@ -1,2 +1,4 @@
 export { default } from './CardContent';
 export * from './CardContent';
+export { default as cardContentClasses } from './cardContentClasses';
+export * from './cardContentClasses';
diff --git a/packages/material-ui/src/CardContent/index.js b/packages/material-ui/src/CardContent/index.js
index 7baf6f04f0efc2..ddb366fe55c431 100644
--- a/packages/material-ui/src/CardContent/index.js
+++ b/packages/material-ui/src/CardContent/index.js
@@ -1 +1,3 @@
 export { default } from './CardContent';
+export { default as cardClasses } from './cardContentClasses';
+export * from './cardContentClasses';