diff --git a/Makefile b/Makefile
index c24acf3f7d0..f83f5a540c0 100644
--- a/Makefile
+++ b/Makefile
@@ -912,9 +912,6 @@ else
 ifeq ($(findstring s390x,$(UNAME_M)),s390x)
 DESTCPU ?= s390x
 else
-ifeq ($(findstring s390,$(UNAME_M)),s390)
-DESTCPU ?= s390
-else
 ifeq ($(findstring OS/390,$(shell uname -s)),OS/390)
 DESTCPU ?= s390x
 else
@@ -944,7 +941,6 @@ endif
 endif
 endif
 endif
-endif
 ifeq ($(DESTCPU),x64)
 ARCH=x64
 else
@@ -957,9 +953,6 @@ else
 ifeq ($(DESTCPU),ppc64)
 ARCH=ppc64
 else
-ifeq ($(DESTCPU),s390)
-ARCH=s390
-else
 ifeq ($(DESTCPU),s390x)
 ARCH=s390x
 else
@@ -973,7 +966,6 @@ endif
 endif
 endif
 endif
-endif
 
 # node and v8 use different arch names (e.g. node 'x86' vs v8 'ia32').
 # pass the proper v8 arch name to $V8_ARCH based on user-specified $DESTCPU.
diff --git a/doc/api/os.md b/doc/api/os.md
index 861b99b6679..625d395e056 100644
--- a/doc/api/os.md
+++ b/doc/api/os.md
@@ -55,8 +55,7 @@ added: v0.5.0
 
 Returns the operating system CPU architecture for which the Node.js binary was
 compiled. Possible values are `'arm'`, `'arm64'`, `'ia32'`, `'loong64'`,
-`'mips'`, `'mipsel'`, `'ppc64'`, `'riscv64'`, `'s390'`, `'s390x'`,
-and `'x64'`.
+`'mips'`, `'mipsel'`, `'ppc64'`, `'riscv64'`, `'s390x'`, and `'x64'`.
 
 The return value is equivalent to [`process.arch`][].
 
@@ -257,7 +256,7 @@ added:
 * Returns: {string}
 
 Returns the machine type as a string, such as `arm`, `arm64`, `aarch64`,
-`mips`, `mips64`, `ppc64`, `ppc64le`, `s390`, `s390x`, `i386`, `i686`, `x86_64`.
+`mips`, `mips64`, `ppc64`, `ppc64le`, `s390x`, `i386`, `i686`, `x86_64`.
 
 On POSIX systems, the machine type is determined by calling
 [`uname(3)`][]. On Windows, `RtlGetVersion()` is used, and if it is not
diff --git a/tools/v8_gypfiles/v8.gyp b/tools/v8_gypfiles/v8.gyp
index df7f37a8013..75cc19d7f0b 100644
--- a/tools/v8_gypfiles/v8.gyp
+++ b/tools/v8_gypfiles/v8.gyp
@@ -773,12 +773,12 @@
           }],
           ['v8_target_arch=="s390x"', {
             'sources': [
-              '<!@pymod_do_main(GN-scraper "<(V8_ROOT)/BUILD.gn"  "v8_header_set.\\"v8_internal_headers\\".*?v8_enable_i18n_support.*?v8_current_cpu == \\"s390\\".*?sources \\+= ")',
+              '<!@pymod_do_main(GN-scraper "<(V8_ROOT)/BUILD.gn"  "v8_header_set.\\"v8_internal_headers\\".*?v8_enable_i18n_support.*?v8_current_cpu == \\"s390x\\".*?sources \\+= ")',
             ],
             'conditions': [
               ['v8_enable_sparkplug==1', {
                 'sources': [
-                  '<!@pymod_do_main(GN-scraper "<(V8_ROOT)/BUILD.gn"  "v8_header_set.\\"v8_internal_headers\\".*?v8_enable_i18n_support.*?v8_current_cpu == \\"s390\\".*?v8_enable_sparkplug.*?sources \\+= ")',
+                  '<!@pymod_do_main(GN-scraper "<(V8_ROOT)/BUILD.gn"  "v8_header_set.\\"v8_internal_headers\\".*?v8_enable_i18n_support.*?v8_current_cpu == \\"s390x\\".*?v8_enable_sparkplug.*?sources \\+= ")',
                 ],
               }],
             ],
@@ -1142,7 +1142,7 @@
         }],
         ['v8_target_arch=="s390x"', {
           'sources': [
-            '<!@pymod_do_main(GN-scraper "<(V8_ROOT)/BUILD.gn"  "\\"v8_base_without_compiler.*?v8_enable_wasm_gdb_remote_debugging.*?v8_current_cpu == \\"s390\\".*?sources \\+= ")',
+            '<!@pymod_do_main(GN-scraper "<(V8_ROOT)/BUILD.gn"  "\\"v8_base_without_compiler.*?v8_enable_wasm_gdb_remote_debugging.*?v8_current_cpu == \\"s390x\\".*?sources \\+= ")',
           ],
         }],
         ['v8_target_arch=="riscv64"', {