diff --git a/.github/workflows/instrumentations_1.yml b/.github/workflows/instrumentations_1.yml
index 8c99eb0572..a658796ef8 100644
--- a/.github/workflows/instrumentations_1.yml
+++ b/.github/workflows/instrumentations_1.yml
@@ -38,6 +38,7 @@ jobs:
           - "resource-detector-azure"
           - "resource-detector-container"
           - "util-http"
+          - "fastapi-slim"
         os: [ubuntu-20.04]
         exclude:
           - python-version: pypy3
diff --git a/CHANGELOG.md b/CHANGELOG.md
index 4228bf1254..7caff5e940 100644
--- a/CHANGELOG.md
+++ b/CHANGELOG.md
@@ -55,8 +55,11 @@ and this project adheres to [Semantic Versioning](https://semver.org/spec/v2.0.0
 - `opentelemetry-instrumentation-httpx`, `opentelemetry-instrumentation-aiohttp-client`,
   `opentelemetry-instrumentation-requests` Populate `{method}` as `HTTP` on `_OTHER` methods
   ([#2726](https://github.com/open-telemetry/opentelemetry-python-contrib/pull/2726))
+- `opentelemetry-instrumentation-fastapi` Add dependency support for fastapi-slim
+  ([#2702](https://github.com/open-telemetry/opentelemetry-python-contrib/pull/2702))
 
 ### Fixed
+
 - Handle `redis.exceptions.WatchError` as a non-error event in redis instrumentation
   ([#2668](https://github.com/open-telemetry/opentelemetry-python-contrib/pull/2668))
 - `opentelemetry-instrumentation-httpx` Ensure httpx.get or httpx.request like methods are instrumented
diff --git a/instrumentation/README.md b/instrumentation/README.md
index 989ba529cb..900ee6ea74 100644
--- a/instrumentation/README.md
+++ b/instrumentation/README.md
@@ -19,7 +19,7 @@
 | [opentelemetry-instrumentation-django](./opentelemetry-instrumentation-django) | django >= 1.10 | Yes | experimental
 | [opentelemetry-instrumentation-elasticsearch](./opentelemetry-instrumentation-elasticsearch) | elasticsearch >= 6.0 | No | experimental
 | [opentelemetry-instrumentation-falcon](./opentelemetry-instrumentation-falcon) | falcon >= 1.4.1, < 4.0.0 | Yes | experimental
-| [opentelemetry-instrumentation-fastapi](./opentelemetry-instrumentation-fastapi) | fastapi ~= 0.58 | Yes | migration
+| [opentelemetry-instrumentation-fastapi](./opentelemetry-instrumentation-fastapi) | fastapi ~= 0.58,fastapi-slim ~= 0.111.0 | Yes | migration
 | [opentelemetry-instrumentation-flask](./opentelemetry-instrumentation-flask) | flask >= 1.0 | Yes | migration
 | [opentelemetry-instrumentation-grpc](./opentelemetry-instrumentation-grpc) | grpcio ~= 1.27 | No | experimental
 | [opentelemetry-instrumentation-httpx](./opentelemetry-instrumentation-httpx) | httpx >= 0.18.0 | No | migration
diff --git a/instrumentation/opentelemetry-instrumentation-fastapi/pyproject.toml b/instrumentation/opentelemetry-instrumentation-fastapi/pyproject.toml
index 7bae75494e..1ef5507504 100644
--- a/instrumentation/opentelemetry-instrumentation-fastapi/pyproject.toml
+++ b/instrumentation/opentelemetry-instrumentation-fastapi/pyproject.toml
@@ -34,7 +34,8 @@ dependencies = [
 
 [project.optional-dependencies]
 instruments = [
-  "fastapi ~= 0.58",
+    "fastapi ~= 0.58",
+    "fastapi-slim ~= 0.111.0",
 ]
 
 [project.entry-points.opentelemetry_instrumentor]
diff --git a/instrumentation/opentelemetry-instrumentation-fastapi/src/opentelemetry/instrumentation/fastapi/__init__.py b/instrumentation/opentelemetry-instrumentation-fastapi/src/opentelemetry/instrumentation/fastapi/__init__.py
index 2f9bbe7314..9356093a45 100644
--- a/instrumentation/opentelemetry-instrumentation-fastapi/src/opentelemetry/instrumentation/fastapi/__init__.py
+++ b/instrumentation/opentelemetry-instrumentation-fastapi/src/opentelemetry/instrumentation/fastapi/__init__.py
@@ -172,6 +172,7 @@ def client_response_hook(span: Span, scope: dict[str, Any], message: dict[str, A
 ---
 """
 import logging
+from importlib.util import find_spec
 from typing import Collection
 
 import fastapi
@@ -189,7 +190,11 @@ def client_response_hook(span: Span, scope: dict[str, Any], message: dict[str, A
     ClientResponseHook,
     ServerRequestHook,
 )
-from opentelemetry.instrumentation.fastapi.package import _instruments
+from opentelemetry.instrumentation.fastapi.package import (
+    _fastapi,
+    _fastapi_slim,
+    _instruments,
+)
 from opentelemetry.instrumentation.fastapi.version import __version__
 from opentelemetry.instrumentation.instrumentor import BaseInstrumentor
 from opentelemetry.metrics import get_meter
@@ -280,6 +285,11 @@ def uninstrument_app(app: fastapi.FastAPI):
         app._is_instrumented_by_opentelemetry = False
 
     def instrumentation_dependencies(self) -> Collection[str]:
+        if find_spec("fastapi") is not None:
+            return (_fastapi,)
+        if find_spec("fastapi_slim") is not None:
+            return (_fastapi_slim,)
+        # If neither is installed, return both as potential dependencies
         return _instruments
 
     def _instrument(self, **kwargs):
diff --git a/instrumentation/opentelemetry-instrumentation-fastapi/src/opentelemetry/instrumentation/fastapi/package.py b/instrumentation/opentelemetry-instrumentation-fastapi/src/opentelemetry/instrumentation/fastapi/package.py
index d95a2cf6d5..55e1059d7a 100644
--- a/instrumentation/opentelemetry-instrumentation-fastapi/src/opentelemetry/instrumentation/fastapi/package.py
+++ b/instrumentation/opentelemetry-instrumentation-fastapi/src/opentelemetry/instrumentation/fastapi/package.py
@@ -13,7 +13,10 @@
 # limitations under the License.
 
 
-_instruments = ("fastapi ~= 0.58",)
+_fastapi = "fastapi ~= 0.58"
+_fastapi_slim = "fastapi-slim ~= 0.111.0"
+
+_instruments = (_fastapi, _fastapi_slim)
 
 _supports_metrics = True
 
diff --git a/instrumentation/opentelemetry-instrumentation-fastapi/test-requirements-slim.txt b/instrumentation/opentelemetry-instrumentation-fastapi/test-requirements-slim.txt
new file mode 100644
index 0000000000..2ea55f1b91
--- /dev/null
+++ b/instrumentation/opentelemetry-instrumentation-fastapi/test-requirements-slim.txt
@@ -0,0 +1,32 @@
+annotated-types==0.6.0
+anyio==4.3.0
+asgiref==3.7.2
+certifi==2024.7.4
+charset-normalizer==3.3.2
+Deprecated==1.2.14
+exceptiongroup==1.2.0
+fastapi-slim==0.111.0
+h11==0.14.0
+httpcore==1.0.4
+httpx==0.27.0
+idna==3.7
+importlib-metadata==6.11.0
+iniconfig==2.0.0
+packaging==24.0
+pluggy==1.5.0
+py-cpuinfo==9.0.0
+pydantic==2.6.2
+pydantic_core==2.16.3
+pytest==7.4.4
+requests==2.32.3
+sniffio==1.3.0
+starlette==0.37.2
+tomli==2.0.1
+typing_extensions==4.9.0
+urllib3==2.2.2
+wrapt==1.16.0
+zipp==3.19.2
+-e opentelemetry-instrumentation
+-e instrumentation/opentelemetry-instrumentation-asgi
+-e util/opentelemetry-util-http
+-e instrumentation/opentelemetry-instrumentation-fastapi
diff --git a/opentelemetry-instrumentation/src/opentelemetry/instrumentation/bootstrap_gen.py b/opentelemetry-instrumentation/src/opentelemetry/instrumentation/bootstrap_gen.py
index 3f4c78862f..9b71a8bdff 100644
--- a/opentelemetry-instrumentation/src/opentelemetry/instrumentation/bootstrap_gen.py
+++ b/opentelemetry-instrumentation/src/opentelemetry/instrumentation/bootstrap_gen.py
@@ -84,6 +84,10 @@
         "library": "fastapi ~= 0.58",
         "instrumentation": "opentelemetry-instrumentation-fastapi==0.47b0.dev",
     },
+    {
+        "library": "fastapi-slim ~= 0.111.0",
+        "instrumentation": "opentelemetry-instrumentation-fastapi==0.47b0.dev",
+    },
     {
         "library": "flask >= 1.0",
         "instrumentation": "opentelemetry-instrumentation-flask==0.47b0.dev",
diff --git a/tox.ini b/tox.ini
index aac890ed7c..4ba434b29b 100644
--- a/tox.ini
+++ b/tox.ini
@@ -116,7 +116,9 @@ envlist =
 
     ; opentelemetry-instrumentation-fastapi
     py3{8,9,10,11,12}-test-instrumentation-fastapi
+    py3{8,9,10,11,12}-test-instrumentation-fastapi-slim
     pypy3-test-instrumentation-fastapi
+    pypy3-test-instrumentation-fastapi-slim
     lint-instrumentation-fastapi
 
     ; opentelemetry-instrumentation-flask
@@ -544,6 +546,11 @@ commands_pre =
   fastapi: pip install opentelemetry-sdk@{env:CORE_REPO}\#egg=opentelemetry-sdk&subdirectory=opentelemetry-sdk
   fastapi: pip install opentelemetry-test-utils@{env:CORE_REPO}\#egg=opentelemetry-test-utils&subdirectory=tests/opentelemetry-test-utils
   fastapi: pip install -r {toxinidir}/instrumentation/opentelemetry-instrumentation-fastapi/test-requirements.txt
+  fastapi-slim: pip install opentelemetry-api@{env:CORE_REPO}\#egg=opentelemetry-api&subdirectory=opentelemetry-api
+  fastapi-slim: pip install opentelemetry-semantic-conventions@{env:CORE_REPO}\#egg=opentelemetry-semantic-conventions&subdirectory=opentelemetry-semantic-conventions
+  fastapi-slim: pip install opentelemetry-sdk@{env:CORE_REPO}\#egg=opentelemetry-sdk&subdirectory=opentelemetry-sdk
+  fastapi-slim: pip install opentelemetry-test-utils@{env:CORE_REPO}\#egg=opentelemetry-test-utils&subdirectory=tests/opentelemetry-test-utils
+  fastapi-slim: pip install -r {toxinidir}/instrumentation/opentelemetry-instrumentation-fastapi/test-requirements-slim.txt
 
   mysql: pip install opentelemetry-api@{env:CORE_REPO}\#egg=opentelemetry-api&subdirectory=opentelemetry-api
   mysql: pip install opentelemetry-semantic-conventions@{env:CORE_REPO}\#egg=opentelemetry-semantic-conventions&subdirectory=opentelemetry-semantic-conventions