diff --git a/doc/whats-new.rst b/doc/whats-new.rst
index 6a8e898c93c..4d4291e050e 100644
--- a/doc/whats-new.rst
+++ b/doc/whats-new.rst
@@ -22,6 +22,9 @@ v2024.06.1 (unreleased)
 
 New Features
 ~~~~~~~~~~~~
+- Allow per-variable specification of ``mask_and_scale``, ``decode_times``, ``decode_timedelta``
+  ``use_cftime`` and ``concat_characters`` params in :py:func:`~xarray.open_dataset`  (:pull:`9218`).
+  By `Mathijs Verhaegh <https://github.com/Ostheer>`_.
 - Allow chunking for arrays with duplicated dimension names (:issue:`8759`, :pull:`9099`).
   By `Martin Raspaud <https://github.com/mraspaud>`_.
 - Extract the source url from fsspec objects (:issue:`9142`, :pull:`8923`).
diff --git a/xarray/backends/api.py b/xarray/backends/api.py
index 521bdf65e6a..ece60a2b161 100644
--- a/xarray/backends/api.py
+++ b/xarray/backends/api.py
@@ -398,11 +398,11 @@ def open_dataset(
     chunks: T_Chunks = None,
     cache: bool | None = None,
     decode_cf: bool | None = None,
-    mask_and_scale: bool | None = None,
-    decode_times: bool | None = None,
-    decode_timedelta: bool | None = None,
-    use_cftime: bool | None = None,
-    concat_characters: bool | None = None,
+    mask_and_scale: bool | Mapping[str, bool] | None = None,
+    decode_times: bool | Mapping[str, bool] | None = None,
+    decode_timedelta: bool | Mapping[str, bool] | None = None,
+    use_cftime: bool | Mapping[str, bool] | None = None,
+    concat_characters: bool | Mapping[str, bool] | None = None,
     decode_coords: Literal["coordinates", "all"] | bool | None = None,
     drop_variables: str | Iterable[str] | None = None,
     inline_array: bool = False,
@@ -451,25 +451,31 @@ def open_dataset(
     decode_cf : bool, optional
         Whether to decode these variables, assuming they were saved according
         to CF conventions.
-    mask_and_scale : bool, optional
+    mask_and_scale : bool or dict-like, optional
         If True, replace array values equal to `_FillValue` with NA and scale
         values according to the formula `original_values * scale_factor +
         add_offset`, where `_FillValue`, `scale_factor` and `add_offset` are
         taken from variable attributes (if they exist).  If the `_FillValue` or
         `missing_value` attribute contains multiple values a warning will be
         issued and all array values matching one of the multiple values will
-        be replaced by NA. This keyword may not be supported by all the backends.
-    decode_times : bool, optional
+        be replaced by NA. Pass a mapping, e.g. ``{"my_variable": False}``,
+        to toggle this feature per-variable individually.
+        This keyword may not be supported by all the backends.
+    decode_times : bool or dict-like, optional
         If True, decode times encoded in the standard NetCDF datetime format
         into datetime objects. Otherwise, leave them encoded as numbers.
+        Pass a mapping, e.g. ``{"my_variable": False}``,
+        to toggle this feature per-variable individually.
         This keyword may not be supported by all the backends.
-    decode_timedelta : bool, optional
+    decode_timedelta : bool or dict-like, optional
         If True, decode variables and coordinates with time units in
         {"days", "hours", "minutes", "seconds", "milliseconds", "microseconds"}
         into timedelta objects. If False, leave them encoded as numbers.
         If None (default), assume the same value of decode_time.
+        Pass a mapping, e.g. ``{"my_variable": False}``,
+        to toggle this feature per-variable individually.
         This keyword may not be supported by all the backends.
-    use_cftime: bool, optional
+    use_cftime: bool or dict-like, optional
         Only relevant if encoded dates come from a standard calendar
         (e.g. "gregorian", "proleptic_gregorian", "standard", or not
         specified).  If None (default), attempt to decode times to
@@ -478,12 +484,16 @@ def open_dataset(
         ``cftime.datetime`` objects, regardless of whether or not they can be
         represented using ``np.datetime64[ns]`` objects.  If False, always
         decode times to ``np.datetime64[ns]`` objects; if this is not possible
-        raise an error. This keyword may not be supported by all the backends.
-    concat_characters : bool, optional
+        raise an error. Pass a mapping, e.g. ``{"my_variable": False}``,
+        to toggle this feature per-variable individually.
+        This keyword may not be supported by all the backends.
+    concat_characters : bool or dict-like, optional
         If True, concatenate along the last dimension of character arrays to
         form string arrays. Dimensions will only be concatenated over (and
         removed) if they have no corresponding variable and if they are only
         used as the last dimension of character arrays.
+        Pass a mapping, e.g. ``{"my_variable": False}``,
+        to toggle this feature per-variable individually.
         This keyword may not be supported by all the backends.
     decode_coords : bool or {"coordinates", "all"}, optional
         Controls which variables are set as coordinate variables:
diff --git a/xarray/conventions.py b/xarray/conventions.py
index 6eff45c5b2d..ff1256883ba 100644
--- a/xarray/conventions.py
+++ b/xarray/conventions.py
@@ -2,7 +2,7 @@
 
 from collections import defaultdict
 from collections.abc import Hashable, Iterable, Mapping, MutableMapping
-from typing import TYPE_CHECKING, Any, Literal, Union
+from typing import TYPE_CHECKING, Any, Literal, TypeVar, Union
 
 import numpy as np
 import pandas as pd
@@ -384,16 +384,26 @@ def _update_bounds_encoding(variables: T_Variables) -> None:
                     bounds_encoding.setdefault("calendar", encoding["calendar"])
 
 
+T = TypeVar("T")
+
+
+def _item_or_default(obj: Mapping[Any, T] | T, key: Hashable, default: T) -> T:
+    """
+    Return item by key if obj is mapping and key is present, else return default value.
+    """
+    return obj.get(key, default) if isinstance(obj, Mapping) else obj
+
+
 def decode_cf_variables(
     variables: T_Variables,
     attributes: T_Attrs,
-    concat_characters: bool = True,
-    mask_and_scale: bool = True,
-    decode_times: bool = True,
+    concat_characters: bool | Mapping[str, bool] = True,
+    mask_and_scale: bool | Mapping[str, bool] = True,
+    decode_times: bool | Mapping[str, bool] = True,
     decode_coords: bool | Literal["coordinates", "all"] = True,
     drop_variables: T_DropVariables = None,
-    use_cftime: bool | None = None,
-    decode_timedelta: bool | None = None,
+    use_cftime: bool | Mapping[str, bool] | None = None,
+    decode_timedelta: bool | Mapping[str, bool] | None = None,
 ) -> tuple[T_Variables, T_Attrs, set[Hashable]]:
     """
     Decode several CF encoded variables.
@@ -431,7 +441,7 @@ def stackable(dim: Hashable) -> bool:
         if k in drop_variables:
             continue
         stack_char_dim = (
-            concat_characters
+            _item_or_default(concat_characters, k, True)
             and v.dtype == "S1"
             and v.ndim > 0
             and stackable(v.dims[-1])
@@ -440,12 +450,12 @@ def stackable(dim: Hashable) -> bool:
             new_vars[k] = decode_cf_variable(
                 k,
                 v,
-                concat_characters=concat_characters,
-                mask_and_scale=mask_and_scale,
-                decode_times=decode_times,
+                concat_characters=_item_or_default(concat_characters, k, True),
+                mask_and_scale=_item_or_default(mask_and_scale, k, True),
+                decode_times=_item_or_default(decode_times, k, True),
                 stack_char_dim=stack_char_dim,
-                use_cftime=use_cftime,
-                decode_timedelta=decode_timedelta,
+                use_cftime=_item_or_default(use_cftime, k, None),
+                decode_timedelta=_item_or_default(decode_timedelta, k, None),
             )
         except Exception as e:
             raise type(e)(f"Failed to decode variable {k!r}: {e}") from e