diff --git a/Tests/images/bc5u.dds b/Tests/images/bc5u.dds
new file mode 100644
index 00000000000..4e4773cd717
Binary files /dev/null and b/Tests/images/bc5u.dds differ
diff --git a/Tests/test_file_dds.py b/Tests/test_file_dds.py
index cac4108a8f0..ae4831d4848 100644
--- a/Tests/test_file_dds.py
+++ b/Tests/test_file_dds.py
@@ -16,6 +16,7 @@
 TEST_FILE_DX10_BC5_UNORM = "Tests/images/bc5_unorm.dds"
 TEST_FILE_DX10_BC5_SNORM = "Tests/images/bc5_snorm.dds"
 TEST_FILE_BC5S = "Tests/images/bc5s.dds"
+TEST_FILE_BC5U = "Tests/images/bc5u.dds"
 TEST_FILE_BC6H = "Tests/images/bc6h.dds"
 TEST_FILE_BC6HS = "Tests/images/bc6h_sf.dds"
 TEST_FILE_DX10_BC7 = "Tests/images/bc7-argb-8bpp_MipMaps-1.dds"
@@ -81,10 +82,18 @@ def test_sanity_ati1():
         assert_image_equal_tofile(im, TEST_FILE_ATI1.replace(".dds", ".png"))
 
 
-def test_sanity_ati2():
-    """Check ATI2 images can be opened"""
+@pytest.mark.parametrize(
+    "image_path",
+    (
+        TEST_FILE_ATI2,
+        # hexeditted to use BC5U FourCC
+        TEST_FILE_BC5U,
+    ),
+)
+def test_sanity_ati2_bc5u(image_path):
+    """Check ATI2 and BC5U images can be opened"""
 
-    with Image.open(TEST_FILE_ATI2) as im:
+    with Image.open(image_path) as im:
         im.load()
 
         assert im.format == "DDS"
diff --git a/src/PIL/DdsImagePlugin.py b/src/PIL/DdsImagePlugin.py
index 1368ae24e59..4da33332edf 100644
--- a/src/PIL/DdsImagePlugin.py
+++ b/src/PIL/DdsImagePlugin.py
@@ -173,7 +173,7 @@ def _open(self):
                 self.pixel_format = "BC4"
                 n = 4
                 self._mode = "L"
-            elif fourcc == b"ATI2":
+            elif fourcc in (b"ATI2", b"BC5U"):
                 self.pixel_format = "BC5"
                 n = 5
                 self._mode = "RGB"