diff --git a/Tests/test_file_libtiff.py b/Tests/test_file_libtiff.py
index 22bcd285622..20c0bae9218 100644
--- a/Tests/test_file_libtiff.py
+++ b/Tests/test_file_libtiff.py
@@ -685,13 +685,18 @@ def test_save_ycbcr(self, tmp_path: Path) -> None:
             assert reloaded.tag_v2[530] == (1, 1)
             assert reloaded.tag_v2[532] == (0, 255, 128, 255, 128, 255)
 
-    def test_exif_ifd(self, tmp_path: Path) -> None:
-        outfile = str(tmp_path / "temp.tif")
+    def test_exif_ifd(self) -> None:
+        out = io.BytesIO()
         with Image.open("Tests/images/tiff_adobe_deflate.tif") as im:
             assert im.tag_v2[34665] == 125456
-            im.save(outfile)
+            im.save(out, "TIFF")
 
-        with Image.open(outfile) as reloaded:
+            with Image.open(out) as reloaded:
+                assert 34665 not in reloaded.tag_v2
+
+            im.save(out, "TIFF", tiffinfo={34665: 125456})
+
+        with Image.open(out) as reloaded:
             if Image.core.libtiff_support_custom_tags:
                 assert reloaded.tag_v2[34665] == 125456
 
diff --git a/src/PIL/TiffImagePlugin.py b/src/PIL/TiffImagePlugin.py
index 04f36744bed..ab5934816ba 100644
--- a/src/PIL/TiffImagePlugin.py
+++ b/src/PIL/TiffImagePlugin.py
@@ -1816,11 +1816,15 @@ def _save(im, fp, filename):
         if hasattr(im, "tag"):
             legacy_ifd = im.tag.to_v2()
 
-        # SAMPLEFORMAT is determined by the image format and should not be copied
-        # from legacy_ifd.
         supplied_tags = {**getattr(im, "tag_v2", {}), **legacy_ifd}
-        if SAMPLEFORMAT in supplied_tags:
-            del supplied_tags[SAMPLEFORMAT]
+        for tag in (
+            # IFD offset that may not be correct in the saved image
+            EXIFIFD,
+            # Determined by the image format and should not be copied from legacy_ifd.
+            SAMPLEFORMAT,
+        ):
+            if tag in supplied_tags:
+                del supplied_tags[tag]
 
         for tag, value in itertools.chain(ifd.items(), supplied_tags.items()):
             # Libtiff can only process certain core items without adding