diff --git a/CHANGELOG.md b/CHANGELOG.md
index a6165d9c..18d5f370 100644
--- a/CHANGELOG.md
+++ b/CHANGELOG.md
@@ -1,3 +1,9 @@
+# Unreleased
+
+- Skip a problematic test on Python 3.12.0b1. The test fails on 3.12.0b1 due to
+  a bug in CPython, which will be fixed in 3.12.0b2. The
+  `typing_extensions` test suite now passes on 3.12.0b1.
+
 # Release 4.6.2 (May 25, 2023)
 
 - Fix use of `@deprecated` on classes with `__new__` but no `__init__`.
diff --git a/src/test_typing_extensions.py b/src/test_typing_extensions.py
index fd2a91c3..ac0a2691 100644
--- a/src/test_typing_extensions.py
+++ b/src/test_typing_extensions.py
@@ -2267,6 +2267,10 @@ class Foo: ...
         del f.x
         self.assertNotIsInstance(f, HasX)
 
+    @skipIf(
+        sys.version_info == (3, 12, 0, 'beta', 1),
+        "CPython had a bug in 3.12.0b1"
+    )
     def test_protocols_isinstance_generic_classes(self):
         T = TypeVar("T")