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Merge pull request #266 from sbmlteam/sk-old-bkup
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<?xml version="1.0" encoding="UTF-8"?> | ||
<sbml xmlns="http://www.sbml.org/sbml/level3/version1/core" xmlns:layout="http://www.sbml.org/sbml/level3/version1/layout/version1" xmlns:render="http://www.sbml.org/sbml/level3/version1/render/version1" level="3" version="1" layout:required="false" render:required="false"> | ||
<model metaid="COPASI0" id="New_Model" name="Greene2019 - Differentiate Spontaneous and Induced Evolution to Drug Resistance During Cancer Treatment" substanceUnits="substance" timeUnits="time" volumeUnits="volume" areaUnits="area" lengthUnits="length" extentUnits="substance"> | ||
<listOfUnitDefinitions> | ||
<unitDefinition id="length" name="length"> | ||
<listOfUnits> | ||
<unit kind="metre" exponent="1" scale="0" multiplier="1"/> | ||
</listOfUnits> | ||
</unitDefinition> | ||
<unitDefinition id="area" name="area"> | ||
<listOfUnits> | ||
<unit kind="metre" exponent="2" scale="0" multiplier="1"/> | ||
</listOfUnits> | ||
</unitDefinition> | ||
<unitDefinition id="volume" name="volume"> | ||
<listOfUnits> | ||
<unit kind="litre" exponent="1" scale="-3" multiplier="1"/> | ||
</listOfUnits> | ||
</unitDefinition> | ||
<unitDefinition id="time" name="time"> | ||
<listOfUnits> | ||
<unit kind="second" exponent="1" scale="0" multiplier="1"/> | ||
</listOfUnits> | ||
</unitDefinition> | ||
<unitDefinition id="substance" name="substance"> | ||
<listOfUnits> | ||
<unit kind="mole" exponent="1" scale="-3" multiplier="1"/> | ||
</listOfUnits> | ||
</unitDefinition> | ||
</listOfUnitDefinitions> | ||
<listOfCompartments> | ||
<compartment metaid="COPASI1" id="compartment" name="compartment" spatialDimensions="3" size="1" units="volume" constant="true"/> | ||
</listOfCompartments> | ||
<listOfParameters> | ||
<parameter metaid="COPASI5" id="S_0" name="S_0" value="0.01" constant="true"/> | ||
<parameter metaid="COPASI6" id="R_0" name="R_0" value="0" constant="true"/> | ||
<parameter metaid="COPASI7" id="V_d" name="V_d" value="0.1" constant="true"/> | ||
<parameter metaid="COPASI8" id="V_c" name="V_c" value="0.9" constant="true"/> | ||
<parameter metaid="COPASI9" id="epsilon" name="epsilon" value="1e-06" constant="true"/> | ||
<parameter metaid="COPASI10" id="d" name="d" value="1" constant="true"/> | ||
<parameter metaid="COPASI11" id="p_r" name="p_r" value="0.2" constant="true"/> | ||
<parameter metaid="COPASI12" id="u_on" name="u_on" value="1.5" constant="true"/> | ||
<parameter metaid="COPASI13" id="delta_ton" name="delta_ton" value="1" constant="true"/> | ||
<parameter metaid="COPASI14" id="delta_toff" name="delta_toff" value="3" constant="true"/> | ||
<parameter metaid="COPASI15" id="u" name="u" value="0" constant="false"/> | ||
<parameter metaid="COPASI16" id="alpha" name="alpha" value="0.01" constant="true"/> | ||
<parameter metaid="COPASI4" id="Tumor_Volume_V" name="Tumor Volume V" value="0.01" constant="false"/> | ||
<parameter metaid="COPASI3" id="Sensitive_tumor_S" name="Sensitive tumor S" value="0.01" constant="false"/> | ||
<parameter metaid="COPASI2" id="Resistant_tumor_R" name="Resistant tumor R" value="0" constant="false"/> | ||
</listOfParameters> | ||
<listOfInitialAssignments> | ||
<initialAssignment symbol="Sensitive_tumor_S"> | ||
<math xmlns="http://www.w3.org/1998/Math/MathML"> | ||
<ci> S_0 </ci> | ||
</math> | ||
</initialAssignment> | ||
</listOfInitialAssignments> | ||
<listOfRules> | ||
<assignmentRule variable="Tumor_Volume_V"> | ||
<math xmlns="http://www.w3.org/1998/Math/MathML"> | ||
<apply> | ||
<plus/> | ||
<ci> Resistant_tumor_R </ci> | ||
<ci> Sensitive_tumor_S </ci> | ||
</apply> | ||
</math> | ||
</assignmentRule> | ||
<rateRule variable="Resistant_tumor_R"> | ||
<math xmlns="http://www.w3.org/1998/Math/MathML"> | ||
<apply> | ||
<plus/> | ||
<apply> | ||
<times/> | ||
<cn> 1 </cn> | ||
<apply> | ||
<divide/> | ||
<apply> | ||
<times/> | ||
<ci> compartment </ci> | ||
<apply> | ||
<plus/> | ||
<ci> epsilon </ci> | ||
<apply> | ||
<times/> | ||
<ci> alpha </ci> | ||
<ci> u </ci> | ||
</apply> | ||
</apply> | ||
<ci> Sensitive_tumor_S </ci> | ||
</apply> | ||
<ci> compartment </ci> | ||
</apply> | ||
</apply> | ||
<apply> | ||
<times/> | ||
<cn> 1 </cn> | ||
<apply> | ||
<divide/> | ||
<apply> | ||
<times/> | ||
<ci> compartment </ci> | ||
<ci> p_r </ci> | ||
<apply> | ||
<minus/> | ||
<cn> 1 </cn> | ||
<apply> | ||
<plus/> | ||
<ci> Sensitive_tumor_S </ci> | ||
<ci> Resistant_tumor_R </ci> | ||
</apply> | ||
</apply> | ||
<ci> Resistant_tumor_R </ci> | ||
</apply> | ||
<ci> compartment </ci> | ||
</apply> | ||
</apply> | ||
</apply> | ||
</math> | ||
</rateRule> | ||
<rateRule variable="Sensitive_tumor_S"> | ||
<math xmlns="http://www.w3.org/1998/Math/MathML"> | ||
<apply> | ||
<plus/> | ||
<apply> | ||
<times/> | ||
<apply> | ||
<minus/> | ||
<cn> 1 </cn> | ||
</apply> | ||
<apply> | ||
<divide/> | ||
<apply> | ||
<times/> | ||
<ci> compartment </ci> | ||
<apply> | ||
<plus/> | ||
<ci> epsilon </ci> | ||
<apply> | ||
<times/> | ||
<ci> alpha </ci> | ||
<ci> u </ci> | ||
</apply> | ||
</apply> | ||
<ci> Sensitive_tumor_S </ci> | ||
</apply> | ||
<ci> compartment </ci> | ||
</apply> | ||
</apply> | ||
<apply> | ||
<times/> | ||
<cn> 1 </cn> | ||
<apply> | ||
<divide/> | ||
<apply> | ||
<times/> | ||
<ci> compartment </ci> | ||
<apply> | ||
<minus/> | ||
<cn> 1 </cn> | ||
<apply> | ||
<plus/> | ||
<ci> Sensitive_tumor_S </ci> | ||
<ci> Resistant_tumor_R </ci> | ||
</apply> | ||
</apply> | ||
<ci> Sensitive_tumor_S </ci> | ||
</apply> | ||
<ci> compartment </ci> | ||
</apply> | ||
</apply> | ||
<apply> | ||
<times/> | ||
<apply> | ||
<minus/> | ||
<cn> 1 </cn> | ||
</apply> | ||
<apply> | ||
<divide/> | ||
<apply> | ||
<times/> | ||
<ci> compartment </ci> | ||
<ci> d </ci> | ||
<ci> u </ci> | ||
<ci> Sensitive_tumor_S </ci> | ||
</apply> | ||
<ci> compartment </ci> | ||
</apply> | ||
</apply> | ||
</apply> | ||
</math> | ||
</rateRule> | ||
</listOfRules> | ||
<listOfEvents> | ||
<event metaid="COPASI17" id="treatment" name="treatment" useValuesFromTriggerTime="true"> | ||
<trigger initialValue="false" persistent="true"> | ||
<math xmlns="http://www.w3.org/1998/Math/MathML"> | ||
<apply> | ||
<and/> | ||
<apply> | ||
<gt/> | ||
<ci> Tumor_Volume_V </ci> | ||
<ci> V_d </ci> | ||
</apply> | ||
<apply> | ||
<eq/> | ||
<ci> u </ci> | ||
<cn> 0 </cn> | ||
</apply> | ||
</apply> | ||
</math> | ||
</trigger> | ||
<listOfEventAssignments> | ||
<eventAssignment variable="u"> | ||
<math xmlns="http://www.w3.org/1998/Math/MathML"> | ||
<apply> | ||
<plus/> | ||
<ci> u </ci> | ||
<ci> u_on </ci> | ||
</apply> | ||
</math> | ||
</eventAssignment> | ||
</listOfEventAssignments> | ||
</event> | ||
</listOfEvents> | ||
</model> | ||
</sbml> |
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