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We recently changed the way MIDI samples get combined with their whole-genome partners, particularly in issue #462. Those changes caused some strange results, like sample 90154A_HCV in the 22-Mar-2019 run. It mapped nicely to HCV-1a, while its MIDI partner 90154AMIDI_MidHCV mapped nicely to HCV-1a and badly to HCV-3a. However, it now reports resistance for HCV-1a and HCV-3a.
Resistance should only be reported for a genotype if at least one of the four regions has good coverage:
NS3
NS5a
NS5b (whole genome part)
NS5b (MIDI part)
Currently, a region's coverage is considered good if it has average coverage of at least 100, and the start and end positions have coverage of at least 100.
Options for new coverage requirements:
All positions have coverage of at least 100.
All resistance mutation positions for that genotype have coverage of at least 100.
The text was updated successfully, but these errors were encountered:
We recently changed the way MIDI samples get combined with their whole-genome partners, particularly in issue #462. Those changes caused some strange results, like sample 90154A_HCV in the 22-Mar-2019 run. It mapped nicely to HCV-1a, while its MIDI partner 90154AMIDI_MidHCV mapped nicely to HCV-1a and badly to HCV-3a. However, it now reports resistance for HCV-1a and HCV-3a.
Resistance should only be reported for a genotype if at least one of the four regions has good coverage:
Currently, a region's coverage is considered good if it has average coverage of at least 100, and the start and end positions have coverage of at least 100.
Options for new coverage requirements:
The text was updated successfully, but these errors were encountered: